I'm indeed a Lisp fan. I love Lisp-like languages and, when possible, only use languages that offer at least a certain basic set of features that Lisp implementations also provide. But this goes too far: a typesetting system with the structure of TeX, but with Lisp syntax.
Somehow this reminds me of the problems I have with Common Lisp: I like the language, I find most of its features brilliant to divine and I certainly have usable implementations to choose from. I don't use it anyway: I would simply have to write too much text. The identifiers are as long as COBOL syntax elements. Ugh. Similar with Scribe: while the identifiers are short, I have to write all the clutter around it. And I get those wonderful blah-blubb-fasel-blubber identifiers for various control purposes. Who wants to write all that crap? What good is a typesetting system where I have to write more markup than I would write in plain HTML? If I wanted to write that much non-content, I could just use DocBook instead...