Spring Python - no idea what it's worth, I haven't used Spring under Java so far (well, I hardly ever use Java anyway, at most the JVM occasionally), but you read a lot of positive comments about Spring. Here someone has transferred the ideas to Python - there's even a book about it. I don't know, however, whether a framework for a bondage-and-discipline language translates so well to a highly dynamic language like Python. But you could take a look at it in a quiet hour.